Just like 4 million BTC are missing or lost How many ETNs will be lost during the course of time or have already been lost by for example a person dying and never passing on their passwords or private keys to family etc , or losing their paper or cli wallet whilst forgetting their original passwords !
We can say around 5% of the total supply could go into the wild and never be spent or used ! I can only see this as an inadvertent coin burn. No one can really truly put a figure to that but it certainly will happen over time to what degree i dont know its anyones guess !